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Chennai (Tamil Nadu)
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Reference: 1 perforin binds to membranes and undergoes substantial structural re-arrangement to form pores that enable diffusion of granzyme into the target cell [review]pore-forming protein that plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cellspmid: 2, findings show that n-linked glycosylation of the perforin c-terminus at asn549 within the endoplasmic reticulum inhibits oligomerisation of perforin monomers and protects the host cell from premature pore formation; studies reveal a post-translational regulatory mechanism essential for maintaining perforin in an inactive state until its secretion from the inhibitory acidic environment of the secretory granule pmidplays an important role in killing other cells that are recognized as non-self by the immune system, ein transplant rejection or some forms of autoimmune diseasepromotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymescan insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores
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Thane (Maharashtra)
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